Nucleosides Bearing Quinazoline Moiety and Evaluation Their Antimicrobial effects

The present work describes convenient synthesis of the novel Schiff bases 4, 5 and 6 by reaction each previously synthesized quinazolinones 1, 2 3 with p-methoxybenzaldehyde. [2+2] Cycloaddition Reaction former within phenylisothiocyanate affording azatedine derivatives 7 8. Also, quinazolines 1 could be reacted α-bromoglucose tetraacetate giving peracetylated N-glycosides 9 10 which were then deacetylated to afford N-glycosylated 11 12 respectively. On other hand, Dapsone was p-methoxyacetophenone 4-[(4-aminophenyl) sulfonyl]-N-[(1E)-1-(4-methoxyphenyl)ethylidene]aniline 15 was, in turn, 4-chloro-2-ethoxyquinazoline 16 base 17. latter 2-furoyl chloride 18. structures confirmed IR, 1H-NMR, 13C-NMR, MS elemental analysis. antimicrobial activity for these compounds outline, moderate observed new quinazoline proved possess marked against E. coli, S. aureus C. albicans. strong has nearly most .